How do you add a certificate authority (CA) to Ubuntu? Installing a CACopy your certificate in PEM format (the format that has - -- -BEGIN CERTIFICATE- -- - in it) into /usr/local/share/ca- certificates and name it with a . Then run sudo update- ca- certificates. Caveats: This installation only affects products that use this certificate store. Some products may use other certificate stores; if you use those products, you'll need to add this CA certificate to those other certificate stores, too. Firefox Instructions, Chrome Instructions, Java Instructions)Testing The CAYou can verify if this worked by looking for the certificate that you just added in /etc/ssl/certs/ca- certificates. CA's concatenated together). Firefox: Exporting Your Code Signing Certificate as a P12 File. In Firefox, go to Options. In the Options window, click Advanced, next, click the Certificates tab. A PKI (public key infrastructure) enables users of a basically unsecure public network such as the Internet to securely and privately exchange data and money through. You can also use Open. SSL's s_client by trying to connect to a server that you know is using a certificate signed by the CA that you just installed.$ openssl s_client - connect foo. CApath /etc/ssl/certs. CONNECTED(0. 00. 00. C = US, ST = Virginia, O = "Whatever, Inc.", CN = whatever. Address = admin@whatever. C = US, ST = Virginia, L = Arlington, O = "Whatever, Inc.", CN = foo. Certificate chain. C=US/ST=Virginia/L=Arlington/O=Whatever, Inc./CN=foo. C=US/ST=Virginia/O=Whatever, Inc./CN=whatever. Address=admin@whatever. Key- Arg : None. PSK identity: None. PSK identity hint: None. SRP username: None. Start Time: 1. 39. Timeout : 3. 00 (sec). Verify return code: 0 (ok). The first thing to look for is the certificate chain near the top of the output. This should show the CA as the issuer (next to i: ). This tells you that the server is presenting a certificate signed by the CA you're installing. Second, look for the verify return code at the end to be set to 0 (ok).
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He replied that “trump is #1 A1 best president ever” and finally seemed to loosen up and said that if he really is sentenced “it will be a good opportunity to read and reflect and also i can make paper from inside.” But, of course, his email ended with his signature style: “NOW SET ME UP WITH DAT WIFE OF URS.”“Making paper” presumably means that he’d be making money, not a DIY papyrus- production class in prison, though I didn’t ask him to clarify. You never know. I responded by simply asking “What do you plan to read in prison?”Shkreli’s response: I think you are, once again, mistaken. You assert a proposition which isn’t certain. Please think and rephrase. After playing childish games about rephrasing the question, I pressed him for a “top five” books he’d want to read in jail, and Shkreli finally answered. Sort of. 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Kitsap TABLE OF CONTENTS ALL AREA CODES ARE 360 UNLESS OTHERWISE SPECIFIED 2016 MARCOA Publishing, Inc. 4Telephone Directory.Big Money Thinks Small: Biases, Blind Spots, and Smarter Investing (Columbia Business School Publishing) [Joel Tillinghast] on Amazon.com. *FREE* shipping on. Calculators, engineering, mechanical, electrical, electronics, design, construction, manufacturing, consultant, layout, software, chemical, plastic, polymers. Imagine nature without man: Five ways humans could destroy civilization as we know it 8/30/2016 - Nature without man – what a strange mental picture. However, a small proportion of horses may show bleeding at the nostrils after exercise, which is known as epistaxis. Epidemiology[edit]EIPH often occurs in horses that race at high speeds, with the number of affected race horses increasing in proportion to the speed and intensity of the exercise. It may occur in racing Thoroughbreds (flat racing, steeplechasing or jump racing), American Quarter Horses (incidence of 5. Standardbreds (incidence of 4. Arabians, and Appaloosas. EIPH also occurs in eventers, jumpers, polo ponies, endurance horses, draft horses that pull competitively,[1] and horses taking part in Western speed events such as barrel racing,[2]reining and cutting. It is rare in endurance horses or draft breeds.[3]The lowest intensities of exercise which may cause EIPH are intense trotting (4. EIPH occurs less frequently in stallions than mares or geldings.[6]Prevalence[edit]Approximately 4. In one study, all horses endoscoped on at least three separate occasions following racing had EIPH at least once.[8]Epistaxis (blood coming from one or both nostrils) is much less common, occurring in 0. In a survey of over 2. UK Flat and National Hunt (jump) racing, 1. Similar frequencies have been reported in Japan (1. South Africa (1. 6. Korean (8. 4 per 1. Clinical signs[edit]Unless a horse has severe EIPH, with blood present at the nostrils (known as epistaxis), the main sign is usually poor athletic performance; other signs are generally subtle and not easy to detect.[1. Frequent swallowing and coughing in the immediate post- exercise recovery period, and poor appetite post- performance may be suggestive of EIPH. A definitive diagnosis can only be made by endoscopic examination of the trachea. In the case where no blood is visible in the trachea, EIPH in the small airways may still be present and can be confirmed by a bronchoalveolar lavage. Impaired arterial blood gas (oxygen) tensions during intense exercise, increased blood lactate, and rarely death have been noted (likely due to ruptured chordae tendinae or a different mechanism of lung hemorrhage). Epistaxis is diagnosed when blood is visible at either or both nostrils during or following exercise. To confirm whether the blood is coming from the upper or lower airway requires further examination by endoscopy, although in some cases it is not possible to determine the location. In the majority of epistaxis cases, the blood originates from the lung. Epistaxis during or following exercise can less commonly occur as a result of upper airway hemorrhage, for example following head trauma, subepiglottic cysts, atrial fibrillation, or guttural pouch mycoses. Effects on performance[edit]EIPH reduces a horse's racing performance. Severe EIPH (epistaxis) shortens a horse's racing career. Moderate to severe EIPH is associated with a worsened finishing position in a race, and finishing farther behind the winner. Horses with mild EIPH earn more prize money than those with more severe EIPH.[1. While single bouts of EIPH may not even be apparent to the rider, owner or trainer of a horse unless an endoscopic examination is undertaken, the effect on performance within a single race appears to be significant but relatively subtle.[1. In a 2. 00. 5 study, horses finishing races with grade 4 EIPH were on average 6 metres behind those finishing with grade 0.[1. However, the effect of repeated bouts of EIPH that occur with daily training may lead to more significant changes and a greater degree of tissue damage over time[1. Diagnosis[edit]As only one in ten cases of EIPH have epistaxis (bleeding from the nostrils),[1. EIPH,[1. 6] various diagnostic tools are used to diagnose EIPH. Endoscopy. EIPH is most commonly diagnosed by endoscopic examination of the trachea and larger bronchi, with the optimal timing for endoscopy being 6. This post- exercise delay allows time for blood within the lungs to travel to the trachea.[1. Blood can usually be detected in the trachea or bronchi for 1–3 days after an episode of EIPH, but may be present for up to a week.[1. The amount of blood visible in the trachea at the time of examination is most commonly graded on a scale of 0 (no blood) to 4 (airways awash with blood).[1. In some mildly- affected horses, endoscopy must be performed on multiple occasions to confirm a diagnosis of EIPH.[2. The level of restraint required to allow endoscopy to be performed depends on the horse; a nose twitch or sedation may be required.[1. Bronchoalveolar lavage. Bronchoalveolar lavage (BAL) is a procedure whereby a small volume of fluid is put into the airways in order sample the cells and fluids of the aveoli and epithelium of the bronchi.[2. BAL may be performed using a BAL tube, which allows fluid to be added to and removed from the bronchi, or may be performed during endoscopy, if the endoscope has an irrigation channel.[2. To perform BAL, the horse is usually sedated, and local anaesthetic is usually instilled into the airways to reduce coughing.[2. BAL is less useful when severe hemorrhage has occurred. BAL results only reflect the situation in the localized region of the lung which has been lavaged, and may not be representative of the whole lung.[2. The fluid obtained by BAL is submitted for cytological examination. Cytopathology. Cytopathology (examination under a microscope) of either a tracheal wash or a BAL sample can determine whether EIPH has occurred. The number of red blood cells present can be quantified using a hemocytometer. A normal lung wash sample contains fewer than 1. In the case of EIPH, the numbers will be several magnitudes or more higher. The presence of high numbers of hemosiderophages indicate that hemorrhage has occurred in the lung at some time in the past. Hemosiderophages are alveolar macrophages that have ingested and digested red blood cells from previous episodes of EIPH. The end product of the digestion of the red blood cells is an iron- storage complex known as hemosiderin. Radiography. Imaging the lungs by taking a radiograph (x- ray) of the chest cannot be used to diagnose EIPH, as the lungs of affected and unaffected horses share the same characteristics.[2. Pulmonary scintigraphy. Scintigraphy of the lungs may detect moderate to severe alterations in the perfusion and possibly ventilation of the dorso- caudal lung.[2. The use of radio- labelled red blood cells and scintigraphy to localise and or quantify hemorrhage is not useful due to general sequestration of labeled RBC by the lung, even in the absence of hemorrhage.[2. Post- mortem examination. EIPH seldom causes the death of a horse, but if an affected horse dies and undergoes a post- mortem examination, repeated episodes of EIPH will have caused a characteristic blue- gray- brown staining in the lungs.[2. The staining is due to the presence of hemosiderin. The staining is usually most intense in the dorso- caudal region of the left and right diaphragmatic lobes which often progresses cranioventral with repetitive damage. There are often distinct borders between healthy lung tissue and those parts of the lungs that have been affected by EIPH. Other histopathologic findings include fibrosis, bronchial arteryneovascularization, venous remodeling, bronchiolitis, hemosiderin accumulation, increased tissue cellularity (i. EIPH occurs when blood enters the air passages of a horse's lung, due to fractured capillaries. A variety of causes have been proposed, but EIPH is most likely a multi- factorial condition, involving airway, vascular, inflammatory, blood, cardiac, locomotory, and remodelling components. The primary mechanism is likely to be high pulmonary vascular pressures with concurrent negative airway pressures, causing extreme stress across the pulmonary capillary membrane (the fragile membrane separating blood in the pulmonary capillaries from the air- filled alveoli) and consequent hemorrhage into the air spaces of the lung. |
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